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The final proposed mechanism of RBC vasodilation in the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks very first analyzed the nitrite Hb interaction in 1937 and this function was later prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937; D